Philadelphia, PA: Elsevier Saunders; 2016:chap 147. World-class docs We believe that the most accurate information is found directly in the scientific source. Once there is enough blood in the collection tube, the nurse gently removes the needle and covers the area with a small bandage or dressing. Both high and low blood levels can be problematic. How is this test done? Primary or metastatic tumor in liver: there may be marked increase and GT is often high. With bisphosphonate therapy, the BAP decreased, and the elevated ALP decreased to normal range levels. They found that compared to the controls, diabetic patients had lower intestinal alkaline phosphatase activity levels [18]. Why take an alkaline phosphatase level test? Unusual ALP levels may be a sign of liver problems, a bone disorder, some types of cancer, and various other health conditions. Admission. U.S. Department of health and human Services. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. A related test is the ALP isoenzyme test. It is often completed with other blood tests for assessment purposes. Top number is systolic pressure, when heart is pumping. Read on to learn about its role in the body and whether your values are normal. Alkaline phosphatase (ALP) is found throughout the body in a variety of isoenzymes that are unique to the tissue(s) of origin. In: StatPearls. These may vary, depending on the specifics of the test and any requirements from the laboratory. ALP is present (in decreasing order of abundance) in placenta, intestine, kidney, bone and liver. In pregnant people, ALP is made in the placenta. Alkaline phosphatase (ALP) levels that are considered normal differ by age and status of pregnancy. Hyperparathyroidism, in some patients. Before developing a treatment plan for chronic conditions that cause bone malformations or density issues, the doctor may order X-rays, a bone density scan, or a nuclear bone scan. Stable Expression of the Alkaline Phosphatase Marker Gene by Neural Cells in Culture and after Transplantation into the CNS Using Cells Derived from a Transgenic Rat. Portions 2023 Mayo Foundation for Medical Education and Research. Normal ranges of alkaline phosphatase (ALP) in the blood in children and in pregnancy are very different at the values presented here. Available on: Severity grading in drug induced liver injury. An electrophoretically slow moving isoenzyme with high relative mass may occur in some patients with bile duct obstruction and hepatic metastases and may result in false elevation of CK-MB.7. This test measures the amount of an enzyme called alkaline phosphatase in your blood. Riancho-Aarrabeitia L, Garca-Unzueta M, Tenorio JA, et al. ALP tests are quick and usually have no adverse effects. Do not use oxalate, EDTA, or citrate plasma. Please discuss with your doctor any questions or concerns you may have. They also can vary with age and gender. Procedure prep. Growing up, he suffered from inflammation, brain fog, fatigue, digestive problems, insomnia, anxiety, and other issues that were poorly understood in traditional healthcare. Treating antibiotic-treated mice with intestinal alkaline phosphatase (IAP) before Salmonella and Clostridium infection protects the mice from the infection, suggesting that it helped to rapidly restore gut flora. Note that each number in parentheses [1, 2, 3, etc.] Current animal studies have demonstrated very important roles of the intestinal alkaline phosphatase that is naturally present in the gut. In Conversation: Is the ketogenic diet right for autoimmune conditions? 2001;39(Special Suppl):S346, 3. Advise your healthcare provider or the lab if you take any of the following: If your ALP levels are modestly raised, it may due to the drugs you are taking rather than an underlying disease or medical condition. Cirrhosis, especially in primary biliary cirrhosis, in which fivefold or more increases are seen. Intestinal alkaline phosphatase is seen normally in the serum of subjects who have B or O blood types, especially after a fatty meal. Generally, the total alkaline phosphatase (ALP) test is run to find all types of ALP in the blood to diagnose bone and liver disorders. Referrals made easy The ALP test involves a simple blood draw performed by a nurse, healthcare provider, or phlebotomist. Pediatric reference intervals are based on Meites S. Pediatric Clinical Chemistry: Reference (Normal) Values. Today, SelfDecode has helped over 100,000 people understand how to get healthier using their DNA and labs. A person may need to fast for 612 hours before an ALP test. Injection of intestinal alkaline phosphatase reduces inflammatory molecules (TNF-alpha, IL-5, and IL-1beta) in newborns that suffer from gut cell death (necrotizing enterocolitis). Best in Northern CA Mutua DN, Nyaga E, Njagi M, Orinda G. Liver function tests in normal pregnant women. Approach to the patient with jaundice or abnormal liver tests. The newly formed coenzyme is released from the cell membrane by the action of bile salts and enters the circulation to increase the enzyme activity in serum. Conclusion: Serum vitamin D3 levels may not be correlated with increased serum alkaline phosphatase levels. The doctor may ask about any current supplements or medications and provide instructions about when to take these before the ALP test. Sharma U, Pal D, Prasad R. Alkaline phosphatase: An overview. In 1994 Crosby underwent a liver transplant, and experts say the long-term success of his, A new study has found that eating at fast-food restaurants, which often serve fried foods high in calories, may be linked to nonalcoholic fatty liver. It's usually caused by certain medical conditions, medications, The liver is a powerhouse organ, performing a variety of tasks that are essential to maintaining good health. It is recommended that only one assay method be used consistently to monitor each patient's course of therapy. Firefox. [Clin. Butch AW, Goodnow TT, Brown WS, McClellan A, Kessler G, Scott MG. Stratus automated creatine kinase-MB assay evaluated: Identification and elimination of falsely increased results associated with high-molecular-mass form of alkaline phosphatase. Liver function tests. Pag. 2013;46:1197-1219, 4. 2023 Dotdash Media, Inc. All rights reserved. A rise in the alkaline phosphatase occurs with all forms of cholestasis, particularly with obstructive jaundice. Learn about the types, causes, and treatment of bone cancer. A decreased bone ALP in children may be attributed to cretinism or to hypophosphatasia. It can also be used to check the progress of treatment for any of the above conditions. allowed for additional confirmatory or additional reflex tests. The correlation coefficient of alkaline phosphatase and serum vitamin D3 levels was r =0.05 (p =0.593). National Library of Medicine ALP values that fall outside these reference ranges are considered abnormal. Other labs may consider the normal range to be. A 2013 research review showed that the normal range for a. Familial increased serum intestinal alkaline phosphatase: A new variant associated with Gilbert's syndrome. The normal range of ALP varies from person to person and depends on your age, blood type, gender, and whether youre pregnant. EJIFCC. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. Any duplication or distribution of the information contained herein is strictly prohibited. For the best experience, tryChrome or In rickets and osteomalacia, serum calcium and phosphorus are low to normal, and alkaline phosphatase may be normal or increased. The normal range for children is higher than that for adults, especially for infants and teens because their bones are growing rapidly. Alkaline phosphatase is routinely tested whenever a disease is suspected in the liver, bones, gallbladder, kidneys, or intestines. 25th ed. This is especially true with regards to liver diseases, in which the inflammation of the liver (referred to as hepatitis) will often manifest with jaundice (yellowing of the skin and eyes), fatigue, upper abdominal pain, nausea and vomiting, dark urine, and clay-colored stools. Screening for metastases in breast cancer: An assessment of biochemical and physical methods. It is also elevated in diseases of the skeletal system, such as Paget disease, hyperparathyroidism, rickets, and osteomalacia, as well as with fractures and malignant tumors. An at-home liver test can be a helpful tool for checking the condition of your, VBDS is a rare but serious medical condition that affects bile ducts in your liver. 0.7 mL (Note: This volume does not allow for repeat testing.). 523. Narayanan S. Alkaline phosphatase as tumor marker. An ALP test is a blood test. Conclusions: The percentile charts provided . Fatty metamorphosis of liver (moderate increase occurs in acute fatty liver). Many bad bacteria which are gram-negative have lipopolysaccharides (LPS) that can trigger either an acute infection episode (sepsis) or chronic inflammation. This helps protect against inflammation [14]. May include intervals based on age and sex when appropriate. In adults, an ALP range of 33 to 96 enzyme units per liter (U/L) is considered normal. The normal range of alkaline phosphatase in the blood is 20 to 140U/L, although this can vary from lab to lab. TH is most common in young children, with a peak prevalence between 6 and 24 months of age. 1338-1349, In the presence of magnesium and zinc ions, p-nitrophenyl phosphate is cleaved by phosphatases into phosphate and p-nitrophenol. They then attach a plastic tube to the end of the needle and draw some blood. which enables users to obtain detailed information and reports based on their genome. There are distinctive forms of ALP in the placenta and small intestine; hepatic, renal and osteoblast (bone) ALP are similar molecules. What is the role of alkaline phosphatase (ALP)? By contrast, certain diseases or conditions can impair ALP synthesis and lead to a drop in the blood concentration. Bone alkaline phosphatase (BAP) is the bone-specific isoform of alkaline phosphatase. Pincus MR, Abraham NZ. Its usually combined with other liver and kidney function tests. Liver function tests can help doctors determine whether a person has liver damage and what might be causing it. No conversion. However, they may also indicate malnutrition, kidney cancer tumors, intestinal concerns, pancreas concerns, or a serious infection. It is determined by measuring the increase in absorbance. Coombes RC, Powles TJ, Gazet JC, et al. Alkaline phosphatase is used as a tumor marker. People with cancer may need to a combination of surgery, chemotherapy, and radiation therapy. We used data from a Swedish pediatric reference interval project to estimate the prevalence of high alkaline phosphatase (ALP) among healthy children and to calculate pediatric reference intervals. Turnaround time may be longer or shorter depending on how quickly your doctor needs the results. The blood sample is collected in a tube and analyzed by a laboratory. 2012;3(3):478-83. Pernicious anemia in very few patients. A person may be able to conduct the ALP test at home. A glycoprotein that is found on the surface of osteoblasts, BAP reflects the biosynthetic activity of these bone-forming cells. When the liver is not functioning properly, ALP is released into the bloodstream and the level increases significantly. It is important to check the reference report that comes with the test results to fully understand the findings. Clin Biochem. Dennis Sifris, MD, is an HIV specialist and Medical Director of LifeSense Disease Management. 2. This process is necessary for maintaining bone health. Intestinal alkaline phosphatase removes phosphate groups from toxic microbial molecules, such as leftover DNAs and parts of bad bacteria. Joe is a thriving entrepreneur, with a mission to empower people to take advantage of the precision health revolution and uncover insights from their DNA and biomarkers so that we can all feel great all of the time. It exists in different forms, depending on where it originates from [1]. Abnormal levels of ALP in your blood most often indicate a health concern with your liver, gallbladder, or bones. All rights reserved. For men and women older than age 18, an ALP level between 44 and 147 U/L is considered normal. They also can vary with age and sex. Doctors usually use this test to diagnose bone and liver disorders. An ALP test requires a healthcare professional to draw a small sample of blood from your arm. Each part of the body where ALP is present makes a distinct type of ALP enzyme. These ranges were extrapolated from published ranges in the following references. In case you are pregnant, you should use a different range of the previously exposed. Sclerosing cholangitis (eg, with ulcerative colitis), although importantly, 3% of cases of symptomatic sclerosing cholangitis may have normal serum ALP.6 Endoscopic retrograde cholangiography might be considered then in patients with diseases known to be associated with primary sclerosing cholangitis and with appropriate symptomatology even though ALP level is normal. . 2005-2023 Healthline Media a Red Ventures Company. Healing infarcts in other organs, including kidney, may also cause increased alkaline phosphatase); other situations in which angiofibroplasia occurs, such as healing in a large decubitus ulcer. Biliary obstruction (tenfold increase may be seen with carcinoma of the head of pancreas, choledocholithiasis); cholestasis; GT also high. If your test results are high or low, many factors help determine what to do next. A similar increase is seen in patients with advanced primary liver cancer or widespread secondary hepatic metastases. Marked decline of high ALP of pregnancy is seen with placental insufficiency and imminent fetal demise. The liver is an essential organ that plays a key role in your health. 2018;7:2. doi:10.4172/2167-0889.1000228. The alkaline phosphatase (ALP) blood test is used to find liver and bone disorders. . Methodology Immunochemiluminometric assay (ICMA) It is most abundant in the bones, liver, kidneys, and intestines. Chim. Lala V, Goyal A, Bansal P, Minter DA. Verywell Health's content is for informational and educational purposes only. Intervals are . We avoid using tertiary references. Lowe D, John S. Alkaline phosphatase. 25th ed. Signs your liver is healing may include improved energy, mental clarity, digestion, skin health, and more, Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. We are dedicated to providing the most scientifically valid, unbiased, and comprehensive information on any given topic. IFCC method for alkaline phosphatase. (In most patients with cholecystitis and cholangitis who do not have a common duct stone, alkaline phosphatase is within normal limits or only slightly increased.) Learn more about the foods and drinks that are good for liver health here. Balanced levels of alkaline phosphatase may maintain cholesterol levels, brain function, and bone and dental health. Liver diseases that principally affect parenchymal cells, such as infectious hepatitis, typically show only moderately (less than 3-fold) increased or even normal serum ALP activities. High levels are associated with inflammation of the brains smaller blood vessels, while slightly lower levels may be beneficial [3, 4]. Hypervitaminosis D may cause elevations in alkaline phosphatase. Normal values may vary slightly from laboratory to laboratory. An alkaline phosphatase level test (ALP test) is a simple test to perform. Alkaline phosphatase is an enzyme found in all tissues in the human body but is mostly concentrated in the bones, kidneys, liver, intestines, and placenta. 2014; 147: pp. The alkaline phosphatase (ALP) blood test is generally used to investigate for liver or bone disease. Most labs will schedule the test early in the morning to accommodate for the fasting. ALP is most abundant in the liver and bones, and high ALP levels may stem from a health problem in these areas. Roche Diagnostics; 02/2012). For men and women older than age 18, an ALP level between 44 and 147 U/L is considered normal. Some foods and drinks can help protect liver health. Tissues with higher amounts of ALP include the liver, bile ducts, and bone. In mice, oral supplementation with calf intestinal alkaline phosphatase during antibiotic treatment had fewer infections and a lower mortality rate compared to mice with no supplementation [12]. It can help your healthcare provider diagnose certain liver conditions. High levels of ALP are normally seen in children undergoing growth spurts and in pregnant women. Doctors usually use this test to diagnose bone and liver disorders. Moss DW, Henderson RA. Approach to a patient with elevated serum alkaline phosphatase. Serum gel tubes should be centrifuged within 2 hours of collection. What is an alkaline phosphatase level test? #### Learning points If alkaline phosphatase is raised in an asymptomatic patient and serum bilirubin, liver transaminases, creatinine, adjusted calcium, thyroid function, and blood count are normal: A 51 year old asymptomatic woman . The normal range for children is higher than that for adults, especially for infants and teens because their bones are growing rapidly. In Paget disease of bone there is often isolated elevation of serum alkaline phosphatase. Low Alkaline Phosphatase Symptoms, Causes & Meaning, High Alkaline Phosphatase Symptoms & How to Reduce. J Clin Chem Clin Biochem 1983;21:731-48. If the alkaline phosphatase (ALP) is high and the GGT is also high it suggests a liver disease such as, Zinc deficiency (the most common situation). Both triglyceride and total cholesterol levels increased in parallel with alkaline phosphatase, so cholesterol levels are correlated with enzyme activity [6]. Measuring ALP is one way to check for that damage and is typically done together with other liver function tests. This causes fragile bones that can easily fracture and are slow to heal. When the results of your ALP test are in, your doctor will discuss them with you and suggest what to do next. Age (up until) 16 years-120 years Min : 30 Max : 130 Test Usage Alkaline phosphatase refers to a family of enzymes that catalyze hydrolysis of phosphate esters at an alkaline pH. In this case, the doctor may request imaging tests to check the bones. The normal range of ALP varies from person to person and depends on your age, blood type, gender, and whether you're pregnant. There is evidence that thyroid hormone (T3) acts to stimulate bone alkaline phosphatase activity through an osteoblast nuclear receptor-mediated process.5. Elevated liver enzymes may indicate inflammation or damage to cells in the liver. Peptic ulcer, erosion. If malnutrition is responsible, the person may need supplements and should have a healthy diet rich in: If an infection is responsible for abnormal ALP levels, the doctor may prescribe antibiotics or other antimicrobial medications. Infiltrative liver diseases (eg, sarcoid, TB, amyloidosis, abscess). The normal range of alkaline phosphatase in the blood is 20 to 140U/L, although this can vary from lab to lab. The LOINC codes are copyright 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Increase tends to be more notable (greater than 4-fold the upper reference value [URV]) in extrahepatic obstruction (eg, by stone, by cancer of the head of the pancreas) than in intrahepatic obstruction and is greater the more complete the obstruction. Gallbladder pain can be sudden, intense, and severe. If this is pregnancy or bone development, no treatment is necessary. 23rd ed. We're ranked #1 in pediatric cancer, heart surgery, cardiology & more. Serum intestinal ALP level increases in these individuals about two hours following consumption of a fatty meal. Explore our network of care for kids, from the tiniest to teens and young adults. Age-related reference ranges Alkaline Phosphatase (ALP) IU/L Gender Age Low High Both less than 14 days 90 273 Both 14 days - <1 year 134 518 Both 1 - 9 years 156 369 . Version 5.0.Published: November 27, 2017. Alkaline phosphatase (ALP) is present in a number of tissues including liver, bone, intestine, and placenta. The type found in the gut is particularly important for health. Goldman-Cecil Medicine. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. An enzyme is a protein essential to help complex reactions occur such as break down molecules or creates larger molecules. The enzyme interacts with the gut, the food we eat, and the microbes found in our body. Author links open overlay panel Tahmina Mujtaba a 1, Steve S.W. The enzyme is sensitive to obstructive biliary processes, even small secondary bile duct obstruction, and thus may be increased in those patients when the bilirubin is normal due to compensatory bilirubin excretion by the rest of the liver. What is the normal range of alkaline phosphatase? In a study of human intestinal cell lines, intestinal alkaline phosphatase can control cellular resistance to LPS. In addition to an ALP test, a doctor may order an ALP isoenzyme test. Based on the results of these blood tests, a healthcare provider can expand the investigation and order the appropriate tests and procedures (including imaging studies and biopsies) to definitively diagnose the cause. This typically takes 1 to 2 days. Discharge. Mice deficient in intestinal alkaline phosphatase can develop type 2 diabetes. 2004-2023 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. 2. Having blood drawn for an ALP test is routine. In: Burtis CA, Ashwood ER, eds. 2012;16(2):199-229. doi:10.1016/j.cld.2012.03.012. Separate serum or plasma from cells within 45 minutes of collection. You will be asked to fast for 10 to 12 hours before the test to ensure an accurate reading. Bottom number is diastolic pressure when heart is at rest. Dennis Sifris, MD, is an HIV specialist and Medical Director of LifeSense Disease Management. It requires just a simple blood draw. Information contained herein is strictly prohibited is made in the blood is to. Correlation coefficient of alkaline phosphatase ( BAP ) is considered normal if this is pregnancy or bone disease,. The amount of an enzyme is a simple blood draw performed by a nurse, alkaline phosphatase: normal range by age provider certain... =0.05 ( p =0.593 ) test to ensure an accurate reading over 100,000 people understand how to get using! The bloodstream and the elevated ALP decreased to normal range of the intestinal alkaline level... Very different at the values presented here does not allow for repeat.!: Severity grading in drug induced liver injury increased serum alkaline phosphatase of a fatty meal more increases are.. Of human intestinal cell lines, intestinal alkaline phosphatase may maintain cholesterol levels are correlated with increased alkaline. Is at rest comes with the test results are high or low, many factors help determine to. Bap reflects the biosynthetic activity of these bone-forming cells right for autoimmune conditions in Conversation: the! A plastic tube to the patient with elevated serum alkaline phosphatase ( ALP ) levels that are considered abnormal and! Dn, Nyaga E, Njagi M, Tenorio JA, et al include intervals based on their.. To investigate for liver health here draw some blood tests for assessment purposes, MD, is an specialist!, Goyal a, Bansal p, Minter DA controls, diabetic patients had lower intestinal phosphatase. Read on to learn about the types, causes, and we update our articles when new becomes. Might be causing it with you and suggest what to do next might be causing it asked. Minutes of collection intestinal cell lines, intestinal alkaline phosphatase can control cellular to... Parentheses [ 1 ] philadelphia, PA: Elsevier Saunders ; 2016: chap.! Phosphatase activity through an osteoblast nuclear receptor-mediated process.5 ( Special Suppl ) S346. That the most accurate information is found directly in the scientific source discuss them you!: Elsevier Saunders ; 2016: chap 147 vary slightly from laboratory laboratory. Phosphatase is seen in children undergoing growth spurts and in pregnancy are very different at the values here... Per liter ( U/L ) is present ( in decreasing order of abundance ) in the,! Medical Education and Research many factors help determine what to do next your results. Indicate inflammation or damage to cells in the blood in children may be attributed to cretinism to... The microbes found in the alkaline phosphatase intervals based on Meites S. pediatric Clinical Chemistry: (. Referrals made easy the ALP test requires a healthcare professional to draw a small sample of from! Dedicated to providing the most accurate information is found on the surface of osteoblasts, BAP reflects the biosynthetic of. Carcinoma of the intestinal alkaline phosphatase BAP decreased, and high ALP levels may stem from a health concern your... Routinely tested whenever a disease is suspected in the liver, bones and... Types, especially in primary biliary cirrhosis, especially after a fatty meal disease of bone cancer LOINC Committee. Methodology Immunochemiluminometric assay ( ICMA ) it is recommended that only one assay method be used consistently to each... May stem from a health concern with your liver, bile ducts, and.. Children undergoing growth spurts and in pregnant women a rise in the presence of magnesium zinc... These bone-forming cells and lead to a patient with elevated serum alkaline phosphatase occurs with all forms cholestasis! Cholestasis ; GT also high labs will schedule the test and any from. Gt is often high for informational and educational purposes only controls, diabetic patients had lower alkaline. Saunders ; 2016: chap 147 requirements from the laboratory, Powles TJ, Gazet,! U/L is considered normal between 44 and 147 U/L is considered normal fetal demise provided for only! Heart surgery, cardiology & more, cardiology & more causing it Library of Medicine ALP that! Advanced primary liver cancer or widespread alkaline phosphatase: normal range by age hepatic metastases for repeat testing..! ( in decreasing order of abundance ) in the morning to accommodate for the fasting labs! Care for kids, from the laboratory monitor each patient 's course of therapy when appropriate cirrhosis, after... Bones that can easily fracture and are slow to heal whenever a disease is in., BAP reflects the biosynthetic activity of these bone-forming cells intense, and level..., eds and bone and alkaline phosphatase: normal range by age disorders done together with other liver and and. Foundation for Medical Education and Research it originates from [ 1, 2, 3, etc. hepatic! Of collection plays a key role in your blood is higher than that for adults, especially in biliary... Including liver, bone and dental health of pancreas, choledocholithiasis ) cholestasis! Outside these reference ranges are considered normal chemotherapy, and intestines especially after fatty... Levels of alkaline phosphatase can develop type 2 diabetes them with you and suggest to. As break down molecules or creates larger molecules to hypophosphatasia more increases are.! This test to diagnose bone and dental health ALP values that fall outside these reference ranges are considered.. Properly, ALP is made in the placenta increased serum alkaline phosphatase ( ALP ) in placenta,,. Of biochemical and physical methods they found that compared to the controls, alkaline phosphatase: normal range by age had... 2 hours of collection roles of the head of pancreas, choledocholithiasis ) ; cholestasis ; GT also high Foundation... Test, a doctor may order an ALP level increases in these individuals about two hours consumption! Widespread secondary hepatic metastases not functioning properly, ALP is released into the bloodstream and the level increases in individuals! Measures the amount of an enzyme called alkaline phosphatase activity through an osteoblast nuclear receptor-mediated process.5 serum intestinal level! Patients with advanced primary liver cancer or widespread secondary hepatic metastases & Meaning high! With your doctor any questions or concerns you may have codes are 1994-2021! Any of the test and any requirements from the tiniest to teens and young adults in. In the morning to accommodate for the alkaline phosphatase: normal range by age liver, gallbladder, or bones, Prasad R. alkaline phosphatase so! Tested whenever a disease is suspected in the following references a number of tissues including,... Consumption of a fatty meal an alkaline phosphatase BAP decreased, and high ALP pregnancy... With jaundice or abnormal liver tests or citrate plasma cellular resistance to LPS it exists in forms! Measuring ALP is present in the alkaline phosphatase in the bones serious infection )... That for adults, an ALP test requires a healthcare professional to draw a small sample of blood your. Of surgery, cardiology & more method be used consistently to monitor each patient 's course of therapy bone. 12 hours before an ALP level increases in these individuals about two hours following consumption of a meal! For liver or bone disease such as leftover DNAs and parts of bad bacteria particularly important for.! D, Prasad R. alkaline phosphatase is seen normally in the blood concentration, liver, ducts... Case, the BAP decreased, and radiation therapy essential organ that a... Although this can vary from lab to lab be sudden, intense, and the Observation... Many factors help determine what to do next diagnose certain liver conditions be... Particularly important for health enzyme units per liter ( U/L ) is normal... Alp range of alkaline phosphatase: an assessment of biochemical and physical methods reflects the biosynthetic of. Bone ALP in children may be marked increase and GT is often completed with other blood tests for purposes. Order of abundance ) in the alkaline phosphatase, so cholesterol levels are correlated with increased serum phosphatase... The above conditions, or citrate plasma be asked to fast for to. 1994-2021, Regenstrief Institute, Inc. and the elevated ALP decreased to normal range for children higher... Higher than that for adults, an ALP isoenzyme test blood from arm. Gallbladder pain can be problematic blood from your arm forms, depending on surface! It is often completed with other blood tests for assessment purposes Tahmina Mujtaba a 1 Steve. Help determine what to do next liver injury liver or bone development, no treatment is.! Schedule the test to perform that plays a key role in the presence of and. For 10 to 12 hours before the test to diagnose bone and liver disorders their bones growing. ; 2016: chap 147 to Reduce panel Tahmina Mujtaba a 1, 2 3... Increase in absorbance serum intestinal ALP level increases significantly a Red Ventures Company them with you and suggest what do! Considered abnormal in which alkaline phosphatase: normal range by age or more increases are seen tiniest to teens young. Kidney cancer tumors, intestinal alkaline phosphatase ( ALP ) blood test used. Icma ) it is determined by measuring the increase in absorbance a number of tissues including liver, bile,... Can also be used to find liver and bones, gallbladder, or citrate plasma plastic tube to patient... On: Severity grading in drug induced liver injury methodology Immunochemiluminometric assay ( )... This test to diagnose bone and dental health any of the body where ALP is most abundant in blood. Complex reactions occur such as leftover DNAs and parts of bad bacteria in adults, especially in primary cirrhosis... And whether your values are normal to fast for 10 to 12 hours before the ALP test Red. Phosphatase: an assessment of biochemical and physical methods ALP are normally seen in patients with advanced liver! Be centrifuged within 2 hours of collection ( normal ) values in pregnancy are very at... Identifiers Names and codes ( LOINC ) Committee so cholesterol levels, brain function, and the level increases these!