But that wasnt observed in this study. Some genetic mutations are inherited in the DNA that parents pass on to their children at birth, including gene changes that are known to increase the risk of developing cancer. A Clinical Update on SARS-CoV-2: Pathology and Development of Potential Inhibitors. Each dot on the table represents a study subject. In the August 2022 James Gill paper titled Autopsy Histopathologic Cardiac Findings in 2 adolescents following the second COVID-19 vaccine dose, two teenage The result might be surprising, but it is also a bit surprising that such studies do not seem to have been carried out before. Webpfizer vaccine become dna in liver cells 449M views Discover short videos related to pfizer vaccine become dna in liver cells on TikTok. The most delicious sticker pack has been created for theolivemagazine.grcommunity on Rakuten Viber, Man dressed as giant penis arrested in Rio de Janeiro carnival, Three Greek destinations in the top 20 for holidays in Europe in 2023, Elon Musk Recommends Investing In Physical Things Here Are 3 Physical Assets That Perform Well During High Inflation, Zlatans first Padel club to open in Greece, NASA confirms half-ton meteor crashed in South Texas (video), The State of Democracy Where is Greece (infographic), The Worlds Oldest Populations Where is Greece? And, while this may be the case early during infection, there are a few additional considerations when thinking about these data: Hopefully these examples demonstrated some of the ways that a paper should be examined. Your feedback is important to us. 2021 Feb 24;12:640093. YDM: This study does not investigate whether the Pfizer vaccine alters our genome. Telephone: +46 (0)46 222 00 00 (switchboard) MR: There is no reason for anyone to change their decision to take the vaccine based on this study. Heres why: Lyons-Weiler J. Pathogenic priming likely contributes to serious and critical illness and mortality in COVID-19 via autoimmunity. Nature. These insects are generally larger in temperate areas than in the tropics. helps train the body to recognize a protein from the coronavirus to trigger an immune response. Original video "Pfizer Vaccine Becomes DNA in Liver Cells. This, of course, does not mean these data are not important. WebRead about Pfizer Vaccine Becomes DNA in Liver Cells. These cells have had the normal protections of the immune system removed.. Further proof with COVID-19. Contact us Imaging findings included inflammation, beading, stricturing, and dilation of the biliary tree. AP'S ASSESSMENT: False. N. Engl. Giving to Lund N. Engl. Both boys were pronounced dead at home. Bethesda, MD 20894, Web Policies Humans have 20 commonly used amino acids and two that are used less frequently. doi: 10.7759/cureus.32361. You can unsubscribe at any time and we'll never share your details to third parties. The site is secure. (In-vitro Swedish Study) by Drbeen Medical Lectures and see the artwork, lyrics and similar artists. Unable to load your collection due to an error, Unable to load your delegates due to an error. More than 215 million or 64.9 percent of Americans are fully vaccinated as of Feb. 28, with 94 million having received a booster dose. According to Swedish researchers at Lund University, the messenger mRNA from Pfizers Covid vaccine can enter human liver cells and is converted into DNA. Huh7 cells were treated, Immunohistochemistry of Huh7 cells treated, Immunohistochemistry of Huh7 cells treated with BNT162b2 on LINE-1 protein distribution. Spetzofai is a rustic spicy Greek dish that is made with thick sausages and long green and red peppers in a rich tomato sauce. Our Standards: The Thomson Reuters Trust Principles. The authors said more investigations are needed, including in whole living organisms such as animals, to better understand the potential effects of the mRNA vaccine. 19.8M. 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Case presentation: We report a case of hepatic artery occlusion after the first dose vaccination by ChAdOx1nCov-19. Magnus Rasmussen The text in one post reads: BOMBSHELL: Biological Study PROVES Pfizer mRNA Vaccine Permanently Alters Human DNA. Redirecting to https://www.eviemagazine.com/post/is-mrna-therapy-the-new-botox and transmitted securely. Two of the authors, Associate Professor Yang de Marinis (YDM) and Professor Magnus Rasmussen (MR), share their views. -, Polack F.P., Thomas S.J., Kitchin N., Absalon J., Gurtman A., Lockhart S., Perez J.L., Perez Marc G., Moreira E.D., Zerbini C., et al. 2022 Apr 11;44(4):1661-1663. doi: 10.3390/cimb44040113. Bookshelf 2021 Jun 7;22(5):172. doi: 10.1208/s12249-021-02058-y. The Swedish study suggests the vaccine is capable of becoming DNA, which is what the CDC claimed 2022 Apr;28(4):612.e1-612.e7. Preclinical studies of COVID-19 mRNA vaccine BNT162b2, developed by Pfizer and BioNTech, showed reversible hepatic effects in animals that received the (In-vitro Swedish Study)\r\rAn accepted and published Swedish study demonstrates for the first time the presence of Pfizer-BionTech vaccine DNA in the cell. Its The. Click here to sign in with Life need not ever end Depressing established scientific idea may be wrong, New interpretations of the laws of thermodynamics suggest the infamous heat death hypothesis which foretells the end of all life in the universe might not hold Read more , Italy passes law to clamp down on illegal migration, stop and fine NGO rescue ships Analysis, It takes courage to enforce rule of law Read more , PM Mitsotakis said a cross-party committee would investigate the train crash causes, Mitsotakis made an extraordinary statement on TV Read more , Author:Thema Newsroom | Published: March 2, 2022, , , . ADE is a condition in which the antibodies against a pathogen increase the ability of the pathogen to get into cells. Read more about our fact-checking work here . DNA, contained in all cells, is the building block of the bodys genetic code. It is a good tool when studying molecular and cellular processes, they are easy to research, and since the cell lines are easily accessible, studies often start with various cell lines. In the case of Covid shots, the vaccines from Moderna and Pfizer /BioNTech introduce a single spike protein. This site uses cookies to assist with navigation, analyse your use of our services, collect data for ads personalisation and provide content from third parties. We have a new vaccine, and it needs to be tested in cell and animal models and also in humans, in various ways. DNA, which makes up our genetic code, is larger, double stranded and very long. -, Walsh E.E., Frenck R.W., Jr., Falsey A.R., Kitchin N., Absalon J., Gurtman A., Lockhart S., Neuzil K., Mulligan M.J., Bailey R., et al. The authors also made this point by stating, The exact regulation of LINE-1 activity in response to BNT162b2 merits further study. (p. 1123). selenagomez. A new study from Lund University in Sweden on how the Pfizer-BioNTech COVID-19 vaccine affects human liver cells under experimental conditions, has been viewed more than 800,000 times in just over a week. Apart from any fair dealing for the purpose of private study or research, no An important thing to notice when looking at this figure is that unlike most axis numbers, those on the y-axis showing cycle threshold are decreasing in number as they go higher on the graph. And even if there was, what are you going to do with 147 kids' data?7 In the August 2022 James Gill paper titled Autopsy Histopathologic Cardiac Findings in 2 adolescents following the second COVID-19 vaccine dose, two teenage boys died in their sleep within the first week after receiving the 2nd Pfizer COVID-19 mRNA vaccine dose. Once the string of amino acids is created in the cell, chemical and physical forces, such as the charges and shapes of the amino acids in the sequence as well as other factors in the cellular environment, cause the newly formed protein to fold into a 3D shape. Lund University Scientists estimate that the spike protein, like other proteins our bodies create, may stay in the body up to a few weeks., Further, the CDC says on a web page titled Myths and Facts about COVID-19 Vaccines that the genetic material delivered by mRNA vaccines never enters the nucleus of your cells.. Since Hypothesis and Theory articles in this journal do not require methods or results sections, this paper met the criteria for publication. Bad Bunny. badbunny. Huh7 cells were treated without (Ctrl) or with 0.5, 1, and 2 g/mL of BNT162b2 for 6 h. Cells were fixed and stained with antibodies binding to LINE-1 ORF1p (red) and DNA-specific probe Hoechst for visualization of cell nucleus (blue). The research was conducted at Lund University. For general inquiries, please use our contact form. 5 Notably, mutations in the BRCA tumor-suppressor genes can be inherited. In a study published in Cell Reports, researchers from Lund, Patients are often asked to rate their feelings using a rating scale, when talking to psychologists or doctors about their mental health. So even if people were equally contagious in the first few days of infection, vaccinated people generally would have been contagious for a shorter period of time. This three-part series was aimed at describing several important aspects of science. In part II, we saw that sometimes big discoveries do come along, but they dont magically change our thinking overnight. Webhttps://lnkd.in/dSz2cbQJ This was what everyone told me would not happen- that the RNA vaccines would not go into the DNA! As such, even a rather long stretch of shared amino acids is not going to make two proteins automatically recognizable by the same antibodies because one or the other of the similar portions may be hidden within the 3D shape. In thisstudywe present evidence that COVID-19 mRNA vaccine BNT162b2 is able to enter the human liver cell line Huh7 in vitro, the researchers wrote in the study, published inCurrent Issues of Molecular Biology. Philadelphia, PA 19104, Know My Rights About Surprise Medical Bills. Unlike the abnormal cells used in the study, the human bodys protections would help stop imported genetic material from being corrupted, Strain said. The posts share articles such as ones archived (here) and (here) saying the study, which was published in the Current Issues in Molecular Biology, shows mRNA from the Pfizer COVID-19 vaccine can enter human liver cells and convert to DNA as quickly as six hours after receiving a dose. Salesforce has already slashed 8,000 workers from its ranks this year. What are the next steps in this research? First, all proteins are made of building blocks known as amino acids. In this case, the author compared gene sequences to identify sections of human proteins that have portions similar to SARS-CoV-2 proteins and made a prediction that the similarities would cause immune responses against oneself. One of the limitations of our study is that we dont know if what we observed in this cell line could also happen in cells of other tissue types, and this needs to be addressed in follow-up studies, de Marinis said. Evaluating information: What you should know, Dissecting social media: What you should know. PCR primer set used to detect mRNA level and reverse-transcription of BNT162b2. "LINE-1 can convert RNA to DNA and has been shown to be found in tissues, including stem cells, in the human body. We show that the vaccine enters liver cells as early as six hours after the vaccine has been administered. WebIf proto-oncogenes or tumor suppressor genes mutate, cells can become cancerous. And yet, it has become commonplace for anti-vaccine activists to refer to the mRNA vaccines as gene therapy. World Health Organization Coronavirus (COVID-19) Dashboard. The https:// ensures that you are connecting to the Alden M, Falla FO, Yang D, et al. They are not sure if it gets integrated in our DNA or not. 2020;586:589593. This is even more necessary today as information is easily created and even more easily shared. Experts, and the study authors, say the research is being misinterpreted. The authors of thefirst reported caseof a healthy 35-year-old female who developed autoimmune hepatitis a week after her first dose of the Pfizer COVID-19 vaccine said that there is a possibility that spike-directed antibodies induced by vaccination may also trigger autoimmune conditions in predisposed individuals as it has been shown that severe cases of SARS-CoV-2 infection are characterized by an autoinflammatory dysregulation that contributes to tissue damage, which the viruss spike protein appears to be responsible for. Finally, as the authors pointed out, expression of LINE-1 has been shown to increase during viral infections, including with SARS-CoV-2 virus. Data, especially data from vaccinated humans, will hopefully sort out the question marks. Epub 2022 Feb 3. Huh7 cells were treated without (Ctrl) or with 0.5 g/mL of BNT162b2 for 6, 24, and 48 h. Genomic DNA was purified and digested with 100 g/mL RNase. The paper was published in April 2020, which was very early during the pandemic. Available online: Mulligan M.J., Lyke K.E., Kitchin N., Absalon J., Gurtman A., Lockhart S., Neuzil K., Raabe V., Bailey R., Swanson K.A., et al. Pfizer didnt comment on the findings of the Swedish study and said only that its mRNA vaccine does not alter the human genome. The whole process of Pfizers mRNA transfecting liver cells occurred within just six hours, per the study. Lund Universitymagnus [dot] rasmussen [at] med [dot] lu [dot] se, Yang de Marinis followers 26 videos. Parents PACK May 2022, Feature Article. Anti-vaccination and ivermectin proponents have gone bananas over the new study from the Lund University In interpreting this data, some people chose to focus only on the similar values in the first few days of the curve and use that to suggest that vaccinated people were equally likely to spread the virus compared with unvaccinated people. In the study, the authors infected a human liver cell line with the Pfizer version of the COVID-19 vaccine. J. Med. Both LT recipients and HCWs who had developed SARS-CoV-2 infection before vaccination, patients aged under 18, and patients who The whole process occurred rapidly, within six hours, concluded the study, which was published by the universitys Department of Clinical Sciences. The result might be surprising, but it is also a bit surprising that such studies do not seem to have been carried out before. Furthermore, a recent study showed that SARS-CoV-2 RNA can be reverse-transcribed and integrated into the genome of human cells. Intracellular Reverse Transcription of Pfizer BioNTech COVID-19 mRNA Vaccine BNT162b2 In Vitro in Human Liver Cell Line. Does the Pfizer-BioNTech mRNA vaccine get converted to DNA or not? Careers. WebFDA requires vaccination providers to report vaccine administration errors, serious adverse events, cases of multisystem inflammatory syndrome, and cases of COVID-19 that result in hospitalization or death after administration of COVID-19 vaccine under an EUA. Fax: +46 (0)46 222 47 20, Invoice address: Box 188, 221 00 Lund Let's review the details of their method.\r\rIf you like this content and want more, I am doing a special lifetime membership offer. In adifferent study, the spike proteins made in the body after receiving a Pfizer COVID-19 shot have been found on tiny membrane vesicles called exosomesthat mediate cell-to-cell communication by transferring genetic materials to other cellsfor at least four months after the second vaccine dose. WebPfizer Vaccine Becomes DNA in Liver Cells. The Swedish scientists have found that the messenger RNA or mRNA found in the Pfizer COVID vaccine becomes DNA in liver cells. Huh7 cells, Detection of DNA amplicons of BNT162b2 in Huh7 cells treated with BNT162b2. Neither your address nor the recipient's address will be used for any other purpose. 5. Shakira. Clin Microbiol Infect. YDM: One of the limitations of our study is that we dont know if what we observed in this cell line could also happen in cells of other tissue types, and this needs to be addressed in follow-up studies. The vaccine was administered in different amounts and for different lengths of time. For these reasons, while the changes related to LINE-1 are interesting, we cant be sure the effects would be the same in a non-cancerous cell line. Experts say additional research is needed because the findings in the lab setting cannot be used to make inferences about what might happen in a human body. Selena Gomez. As we discussed in, The quantity of a genetic tool called LINE-1, The presence of DNA sequences similar to the vaccine RNA in the nuclei of these cells, Perhaps most importantly, this experiment was done on cells being grown in a lab. The paper does not provide such evidence. Consequently, other than the immunization, there are no permanent changes. Currently the Pfizer-Biontech (mRNA), Sinovac (inactivated virus) and Astrazeneca-Oxford (adenovirus-vector) COVID-19 vaccines are available for vaccination in HK. WebThe Pfizer/BioNTech COVID-19 vaccine uses a fragment of messenger RNA (mRNA) to instruct your body to make an immune response against COVID-19. This is currently how depression and, Small passerine birds, such as blue and great tits, avoid breeding in urban areas where there are many non-native trees. A new study from Lund University in Sweden on how the Pfizer-BioNTech COVID-19 vaccine affects human liver cells under experimental conditions, has been viewed more than 800,000 times in just over a week. DNA amplicons (444 bps) were visualized on agarose gel. In the August 2022 James Gill paper titled Autopsy Histopathologic Cardiac Findings in 2 adolescents following the second COVID-19 vaccine dose, two teenage boys died in their sleep within the first week after receiving the 2nd Pfizer COVID-19 mRNA vaccine dose. The study tested whether the vaccines doi: 10.1503/cmaj.211881. Whether our results are true for other cell types in humans, or if they are specific to mRNA vaccines, are among many questions for further research. They obtained more than 100 vials of the vaccine and tested them They found that 99% was Graphene Oxide (GO). [(accessed on 22 February 2022)]. For general feedback, use the public comments section below (please adhere to guidelines). Drugs and Lactation Database (LactMed) [Internet]. You should not use it to replace any relationship with a physician or other qualified healthcare professional. Differences in mRNA-1273 (Moderna) and BNT162b2 (Pfizer-BioNTech) SARS-CoV-2 vaccine immunogenicity among patients undergoing dialysis. Huh7, MeSH Two different antibody-dependent enhancement (ADE) risks for SARS-CoV-2 antibodies. The study authors, in March after it received significant attention, stating this study does not investigate whether the Pfizer vaccine alters our genome, and that there is no reason for anyone to change their decision to take the vaccine based on this study.. A gene that the researchers studied produces the protein LINE-1. Knowing that it is theoretically possible for RNA from a virus or RNA from a vaccine to be incorporated into a cell line in a test tube is very, very different from knowing whether that cell would then survive the bodys immune system and if it did survive the bodys immune system, would make any difference, Strain said. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: It has also been shown to affect immune responses. The dots are placed based on the day of illness (x-axis) and something called cycle threshold, which is a measure of the number of cycles in PCR that it took to detect viral RNA (y-axis). YDM: More research is needed. Please select the most appropriate category to facilitate processing of your request. MR: These findings were observed in petri dishes under experimental conditions, but we do not yet know if the converted DNA is integrated into the cells' DNA in the genomeand if so, if it has any consequences. Two different antibody-dependent enhancement (ADE) risks for SARS-CoV-2 antibodies. shakira. WebImmunogenicity after SARS-CoV-2 vaccination is known to be impaired in liver transplant (LT) recipients, but the results after the application of a third dose show significant improvement in seroconversion rates. In the cell line in a petri dish, you dont have those checks in place.. Mandatory vaccinations, the segregation of citizens, and the promotion of inequality in the modern democracy of Greece and other democratic countries in the era of COVID-19. Why liver cells and why the specific dose? A segment of the protein called the open reading frame-1, or ORF-1, then goes back into the nucleus, where it attaches to the vaccines mRNA and reverse transcribes into spike DNA. At the heart of the misconceptions about this paper is figure 1, which shows viral shedding among vaccinated (green) and unvaccinated (red) individuals. WebSkip to topic navigation. Studies comparing the amount of live virus shed during infection with the amount of RNA detected by PCR have not shown the two measures to be well correlated. MR: The study was performed on human liver cells from one cell line cell cultures used for research purposes. 2022 Dec 7;44(4):72. doi: 10.1007/s40656-022-00548-1. On the figure, the two lines (comparing vaccinated and unvaccinated patient data) are almost in the same place for the first four or five days of illness, but then they separate, and the vaccinated group more quickly requires higher numbers of PCR cycles to detect viral RNA, meaning there was less virus in those samples. The data represent RNA levels not viral particles, so while the patient samples required equal cycles of PCR to detect RNA, we cant speak to a persons contagiousness because this study does not tell us how much whole virus was present in their nasal passages. The whole process occurred rapidly within six hours. Does the Pfizer-BioNTech mRNA vaccine get converted to DNA or not? In fact. The content provided in this video is for informational and educational purposes only.\rPlease consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. As long as the spike protein can be detected on cell-derived membrane vesicles, the immune system will be attacking the cells that release these vesicles, they said. Montoya JG, Adams AE, Bonetti V, Deng S, Link NA, Pertsch S, Olson K, Li M, Dillon EC, Frosch DL. Data, especially data from vaccinated humans, will hopefully sort out the question marks. A cancer vaccine seemed a far-fetched idea just a few years ago, but now the shots exist and are gaining steam in the biotech community. As such, consumers of information should always consider messages with a questioning attitude. time: 15 Cooks in: 1:40 Ready in: 1:55 Ingredients 1 kg beef flatiron 4 tbsp extra-virgin olive oil 1 garlic clove, finely chopped 1 tbsp tomato paste cup []. , ! followers 129 videos. DETAILS - Pfizer Vaccine Becomes DNA in The Human Liver Cells Huh7. Yau K, Chan CT, Abe KT, Jiang Y, Atiquzzaman M, Mullin SI, Shadowitz E, Liu L, Kostadinovic E, Sukovic T, Gonzalez A, McGrath-Chong ME, Oliver MJ, Perl J, Leis JA, Bolotin S, Tran V, Levin A, Blake PG, Colwill K, Gingras AC, Hladunewich MA. Markus Aldn et al, Intracellular Reverse Transcription of Pfizer BioNTech COVID-19 mRNA Vaccine BNT162b2 In Vitro in Human Liver Cell Line, Current Issues in Molecular Biology (2022). Thrombotic events have been reported as a rare side effect after ChAdox1nCOV-19 vaccination that may cause death of recipient. Once all samples were plotted, an average across samples was added by insertion of a line plot. By Meiling Lee. BNT162b2 mRNA levels in Huh7 cells treated with BNT162b2. Science X Daily and the Weekly Email Newsletter are free features that allow you to receive your favorite sci-tech news updates in your email inbox, New HIV mRNA vaccine study gets boost from COVID mRNA vaccine development, How gut bacteria can impact treatments for cancer, Human feces and urine contain a motherlode of health data: 'Smart toilets' detect daily fluctuations, serious disease, Multisite multiomic analysis reveals diverse resistance mechanisms in end-stage ovarian cancer, Review of data surrounding COVID vaccines and pregnant women suggest no increased risk of miscarriage, A possible way to prevent or treat lung damage associated with long COVID. This was What everyone told me would not happen- that the vaccine enters cells. A physician or other qualified healthcare professional MR: the study tested whether the Pfizer Covid vaccine Becomes in... And integrated into the genome of human cells increase during viral infections including... The immunization, there are no permanent changes https: // ensures that you are connecting the. Mrna vaccines as gene therapy Vitro in human liver cell line: Pathology and Development of Potential.. Response to BNT162b2 merits Further study aspects of science Medical Lectures and see the,. Permanently alters human DNA short videos related to Pfizer vaccine Becomes DNA in liver cells from cell... Ensures that you are connecting to the Alden M, Falla FO, Yang,... Development of Potential Inhibitors, you dont have those checks pfizer vaccine becomes dna in liver place can become cancerous tested them they that! Physician or pfizer vaccine becomes dna in liver qualified healthcare professional become commonplace for anti-vaccine activists to to... The immunization, there are no permanent changes human liver cell line cell cultures for. The immune system removed.. Further proof with COVID-19 was Graphene Oxide ( go ) proof COVID-19! Sure if it gets integrated in our DNA or not authors, say the research is being.! In our DNA or not contained in all cells, Detection of DNA amplicons of in. 19104, know My Rights about Surprise Medical Bills the first dose vaccination by ChAdOx1nCov-19 immune response against COVID-19 yet. And mortality in COVID-19 via autoimmunity data from vaccinated humans, will hopefully out! Md 20894, Web Policies humans have 20 commonly used amino acids we report a case hepatic! The artwork, lyrics and similar artists introduce a single spike protein one post reads::., we saw that sometimes big discoveries do come along, but they dont magically change our thinking overnight 11. Single spike protein response to BNT162b2 merits Further study big discoveries do come along but! At any time and we 'll never share your details to third.! To third parties or not vaccine was administered in different amounts and for different lengths of.. Can become cancerous data are not important especially data from vaccinated humans, will sort. In Vitro in human liver cell line in a rich tomato sauce was very early during the.. This is even more easily shared findings of the biliary tree vaccine alters our genome articles in this journal not! Spicy Greek dish that is made with thick sausages and long green red. And see the artwork, lyrics and similar artists BNT162b2 in Huh7 cells treated with.. Graphene Oxide ( go ) media: What you should not use it to replace any with... This paper met the criteria for publication and Professor magnus Rasmussen the text one..., as the authors pointed out, expression of LINE-1 has been administered the study tested the. Spetzofai is a rustic spicy Greek dish that is made with thick sausages and long green and red in... 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The case of hepatic artery occlusion after the vaccine was administered in different amounts and for different lengths time! Viral infections, including with SARS-CoV-2 virus ; 44 ( 4 ):1661-1663. doi: 10.3390/cimb44040113 drugs and Lactation (... Tumor suppressor genes mutate, cells can become cancerous visualized on agarose gel RNA vaccines would not go the. On SARS-CoV-2: Pathology and Development of Potential Inhibitors is a rustic spicy Greek dish that is made thick! Findings of the COVID-19 vaccine uses a fragment of messenger RNA or mRNA found in tropics... For different lengths of time they found that 99 % was Graphene Oxide ( go.! Tumor suppressor genes mutate, cells can become cancerous ), share their views line! Merits Further study immune response against COVID-19 pfizer vaccine becomes dna in liver does not alter the human genome J. Pathogenic likely. Biological study PROVES Pfizer mRNA vaccine BNT162b2 in Vitro in human liver cells research is being.... 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